Filtered By:
Vaccination: Vaccines
This page shows you your search results in order of date.
Order by Relevance | Date
Total 107327 results found since Jan 2013.
Many Americans Frustrated in Search for Low-Cost COVID Boosters
FRIDAY, Sept. 22, 2023 -- Americans seeking out the new COVID boosters are finding themselves held back by insurance entanglements and supply delays.
Some insurers have balked at covering the vaccines, with people arriving at shot appointments only...
Source: Drugs.com - Daily MedNews - September 22, 2023 Category: General Medicine Source Type: news
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Madhav V Dhodapkar Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets
CONCLUSION: This review summarises important predictive ncRNA biomarkers that were reported in cancer patients treated with different immunotherapeutic modalities, including monoclonal antibodies, small molecule inhibitors, cancer vaccines and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilisation of immunomodulatory ncRNA biomarkers as predictive tools and therapeutic targets.PMID:37735815 | DOI:10.1002/ctm2.1425
Source: Clinical Lung Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Murad Alahdal Eyad Elkord Source Type: research
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 < sup > + < /sup > T cell formation
Sci Immunol. 2023 Sep 29;8(87):eadf7579. doi: 10.1126/sciimmunol.adf7579. Epub 2023 Sep 22.ABSTRACTMitophagy, a central process guarding mitochondrial quality, is commonly impaired in human diseases such as Parkinson's disease, but its impact in adaptive immunity remains unclear. The differentiation and survival of memory CD8+ T cells rely on oxidative metabolism, a process that requires robust mitochondrial quality control. Here, we found that Parkinson's disease patients have a reduced frequency of CD8+ memory T cells compared with healthy donors and failed to form memory T cells upon vaccination against COVID-19, highli...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fabien Franco Alessio Bevilacqua Ruey-Mei Wu Kung-Chi Kao Chun-Pu Lin Lor ène Rousseau Fu-Ti Peng Yu-Ming Chuang Jhan-Jie Peng Jaeoh Park Yingxi Xu Antonino Cassotta Yi-Ru Yu Daniel E Speiser Federica Sallusto Ping-Chih Ho Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Madhav V Dhodapkar Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
A H3K27M-targeted vaccine in adults with diffuse midline glioma
Nat Med. 2023 Sep 21. doi: 10.1038/s41591-023-02555-6. Online ahead of print.ABSTRACTSubstitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide vaccine (H3K27M-vac) induces mutation-specific immune responses that control H3K27M+ tumors in major histocompatibility complex-humanized mice. Here we describe a first-in-human treatment with H3K27M-vac of eight adult patients with progressive H3K27M+ diffuse midline glioma on a compassionate use basis. Five patients received H3K27M-vac combined with anti-PD-1 treat...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Niklas Grassl Isabel Poschke Katharina Lindner Lukas Bunse Iris Mildenberger Tamara Boschert Kristine J ähne Edward W Green Ingrid H ülsmeyer Simone J ünger Tobias Kessler Abigail K Suwala Philipp Eisele Michael O Breckwoldt Peter Vajkoczy Oliver M Gra Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Madhav V Dhodapkar Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity
by Louella M. R. Kasbergen, David F. Nieuwenhuijse, Erwin de Bruin, Reina S. Sikkema, Marion P. G. Koopmans
Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the current knowledge and knowledge gaps in differential arbovirus serology. The search included Medline, Embase and Web of Science databases and identified 911 publications which were reduced to 102 after exclusion of studies not providing data on possible cross-reactivity or...
Source: PLoS Neglected Tropical Diseases - September 22, 2023 Category: Tropical Medicine Authors: Louella M. R. Kasbergen Source Type: research
News at a glance: Diphtheria vaccine shortage, prisoner release, and iNaturalist ’s growth
CONSERVATION
Popular biodiversity app to expand
The nonprofit that runs iNaturalist, a popular app and website for identifying species, has received a $10 million grant to expand. The funding from the Gordon and Betty Moore Foundation, announced last week, will allow iNaturalist—whose website is one of the largest generators of crowd-sourced species-occurrence data—to add users, technology, and observations to inform conservation. iNaturalist hopes to grow in nature-rich parts of the world, such as Asia and South America, which have fewer users uploading data. Since iNaturalist’s founding in 2008, the ...
Source: Science of Aging Knowledge Environment - September 21, 2023 Category: Geriatrics Source Type: research
News at a glance: Diphtheria treatment shortage, prisoner release, and iNaturalist ’s growth
CONSERVATION
Popular biodiversity app to expand
The nonprofit that runs iNaturalist, a popular app and website for identifying species, has received a $10 million grant to expand. The funding from the Gordon and Betty Moore Foundation, announced last week, will allow iNaturalist—whose website is one of the largest generators of crowd-sourced species-occurrence data—to add users, technology, and observations to inform conservation. iNaturalist hopes to grow in nature-rich parts of the world, such as Asia and South America, which have fewer users uploading data. Since iNaturalist’s founding in 2008, the ...
Source: ScienceNOW - September 21, 2023 Category: Science Source Type: news
Continued challenges in pediatric anesthesia during COVID-19 in 2022: An international survey from the pediatric anesthesia COVID-19 collaborative
CONCLUSION: Our study found that COVID-19 has continued to impact pediatric anesthesiology. There are major discrepancies between what anesthesiologists believe are important for job satisfaction and faculty retention compared to implemented initiatives. Data from this survey provide insight for institutions and departments for addressing these challenges.PMID:37732382 | DOI:10.1111/pan.14762
Source: Pain Physician - September 21, 2023 Category: Anesthesiology Authors: John Zhong Victoria Bradford Allison M Fernandez Andrew Infosino Codruta N Soneru Steven J Staffa Vidya T Raman Joseph Cravero David Zurakowski Petra M Meier Pediatric Anesthesia COVID-19 Collaborative Source Type: research
